I had heard of Tod Machover from the pages of KEYBOARD magazine many
years ago when he was working on augmented Cellos. This 20 minute video
of a talk he gave at TED this year is fascinating, but from about the 13 minute mark on, it actually brought me to tears:

http://www.ted.com/index.php/talks/view/id/246

I was reminded of William Horwood's book Scallagrigg, which also blends the themes of Cerebral Palsy and Computer Software, and enablement.